Trial

Amiodarone patients

Placebo patients

Daily amiodarone maintenance dose (mg)

Follow-up (months)

Mortality benefit

Cancer in placebo group

Cancer in amiodarone group

Hamer et al. (1989)12

19

15

200

23

No

0

2* (10.5%)

Ceremuzynski

et al. (1992)10

305

308

400

12

Yes

0

1—stomach cancer (0.3%)

Cairns et al. (1997)13

606

596

200

21

Yes

0

1—metastatic ovarian cancer (0.2%)

Julian et al. (1997)5

743

743

200

21

No

4 (0.5%)

6* (0.8%)

Elizari et al. (2000)14

542

531

high & low

6

No

0

4*—determined to be present prior to enrollment

Roy et al. (2000)15

201

202 (sotalol or propafenone)

200

short

duration

NA

?*,+

?*,+